姓名：刘慧慧
职称：教授
学术职衔：硕士生导师
研究方向：海洋生物学
Email：liuhuihui2004@126.cm
学习工作简历
1997年9月至2001年7月辽宁师范大学生命科学学院学士
2001年9月至2004年7月宁波大学生命科学与生物工程学院硕士
2004年8月至2014年11月浙江海洋大学海洋科学与技术学院讲师
2008年9月至2014年6月浙江大学生命科学学院博士（在职）
2014年12月起浙江海洋大学海洋科学与技术学院教授
教学情况
承担本科生课程《分子生物学（双语）》、《现代生物技术》、《基因工程》、《蛋白质工程》
研究生课程《高级分子生物学》、《现代生物技术》
指导本科生毕业设计和课程设计
科研项目
（1）国家星火计划项目，曼氏无针乌贼抗病苗种培育技术研发与示范，项目编号：2012GA700111，2012.01-2013.12。课题主持人。
（2）浙江省自然科学基金，TLR介导曼氏无针乌贼抗哈维氏弧菌感染的机制与功能，项目编号：LY14C190004，2014.01-2016.12。课题主持人。
（3）舟山市科技计划项目，拟目乌贼抗逆苗种选育关键技术研发与示范，项目编号：2015C41014,2015.09-2018.09。课题主持人。
（4）国家自然科学基金，大黄鱼清道夫受体MARCO抗哈维氏弧菌感染的分子机制，项目编号：41606148，2017.01-2019.12。课题主持人。
（5）浙江省自然科学基金，黄姑鱼清道夫受体MARCO内吞机制及其在免疫应答中的功能，项目编号：LY20C190006，2020.01-2022.12。课题主持人。
代表性论文著作
1.Hui-Hui Liu，Li-Xin Xiang, Jian-Zhong Shao. A novel C1q-domain-containing (C1qDC) protein from Mytilus coruscus with the transcriptional analysis against marine pathogens and heavy metals.Developmental and Comparative Immunology. 2014，44：70-75.
2.Hui-hui Liu，Jian-yu He，Chang-feng Chi，Jianzhong Shao.Differential HSP70 expression inMytilus coruscusunder various stressors. Gene, 2014，543：166-173.
3. Jian-yu He，Chang-feng Chi,Hui-hui Liu(通讯）. Identification and analysis of an intracellular Cu/Zn superoxide dismutase from Sepiella maindroni under stress of Vibrio harveyi and Cd2+. Developmental and Comparative Immunology. 2014, 47 :1–5.
4. Jianyu He,Huihui Liu, Changwen Wu. Identification of SCARA3, SCARA5 and MARCO of class A scavenger receptor-like family in Pseudosciaena crocea. Fish & Shellfish Immunology. 2014, 41:238-249.
5.Huihui Liu，Jianyu He, Changfeng Chi，Yifeng Gu. Identification and analysis of icCu/Zn-SOD, Mn-SOD and ecCu/Zn-SOD in superoxide dismutase multigene family ofPseudosciaena crocea. Fish & Shellfish Immunology, 2015, 43: 491-501.
6.Jianyu He, Wei Liu, Shaoping Wang, Wan Liu,Huihui Liu(通讯）. The SREC-I and SREC-II associated with epidermal growth factor in scavenger receptor family are the potential regulative transmembrane receptors inLarimichthys crocea. Fish & Shellfish Immunology, 2015, 47:182-195.
7.Huihui Liu, Jianyu He, Rongtao Zhao, Changfeng Chi, Yongbo Bao. A novel biomarker for marine environmental pollution of pi-class glutathione S-transferase fromMytilus coruscus. Ecotoxicology and Environmental Safety, 2015, 118: 47-54.
8.Hui-hui Liu, Jian-yu He, Chang-feng Chi, Zhen-ming Lv. Identification and analysis of HSP70 fromSepiella maindroniunder stress ofVibrio harveyiand Cd2+.Gene, 2015，572：146-152.
9.Jian-yu He, Junru Wang, Mengshan Xu, Changwen Wu,Huihui Liu（通讯）.The cooperative expression of Heat Shock Protein 70 KD and 90 KDgene in juvenileLarimichthys croceaunderVibrio alginolyticusstress. Fish & Shellfish Immunology , 2016,58: 359-369.
10.Hui-hui Liu,Jiong Wu, Mengshan Xu, Jianyu He.A novel biomarker for marine environmental pollution of HSP90 fromMytilus coruscus. Marine Pollution Bulletin, 2016,111, 428–434.
11.Jianyu He,Hui-hui Liu,JingwenYang,XiangliDong,Changwen Wu.Abundant members of Scavenger receptors family and their identification, characterization and expression againstVibrio alginolyticusinfection in juvenileLarimichthys crocea.Fish & Shellfish Immunology , 2016, 50: 297-309.
12 Jiong Wu, Miaomiao Bao, Delong Ge, Liping Huo, Zhenming Lv, Changfeng Chi, Zhi Liao, Huihui Liu（通讯）.The expression of superoxide dismutase in Mytilus coruscus undervarious stressors.Fish & Shellfish Immunology. 2017，70 ：361-371.
12.Mengshan Xu, Jiong Wu, Delong Ge, Changwen Wu, Changfeng Chi, Zhenming Lv, Zhi Liao,Huihui Liu（通讯）. A novel toll-like receptor from Mytilus coruscus is induced in response to stress.Fish & Shellfish Immunology. 2018，78：331-337.
13.Liping Huo, Miaomiao Bao, Zhenming Lv, Changfeng Chi, Tianming Wang,Huihui Liu（通讯）. Identification, functional characterization andexpression pattern of myeloid differentiation factor 88 (MyD88) in Sepiella japonica[J]. Fish and Shellfish Immunology, 2018, 79: 112-119.
14.Miaomiao Bao, Liping Huo, Jiong Wu, Delong Ge, Zhenming Lv, Changfeng Chi, Zhi Liao,Huihui Liu（通讯）.A novel biomarker for marine environmental pollution of CAT from Mytilus coruscus. Marine Pollution Bulletin, 2018,127：717-725.
15.Huihui Liu, Liping Huo, Qiuhan Yu, Delong Ge, Changfeng Chi∗, Zhenming Lv, Tianming Wang.Molecular insights of a novel cephalopod toll-like receptor homologue in Sepiella japonica, revealing its function under the stress of aquatic pathogenic bacteria. Fish and Shellfish Immunology, 2019, 90: 297-309.
16.Junxi Xiang, Ruiyi Chen, Dongdong Xu,Yibo Sun,Huihui Liu（通讯）. Characterization of pathological changes and immune-related gene expression in yellow drum (Nibea albiflora) in response to Pseudomonas plecoglossicida and poly I:C challenge. Aquaculture Reports, 2020，17：100350.
17.Sijia Liu, Delong Ge, Zaihao Long, Changfeng Chi, Zhenming Lv,Huihui Liu（通讯）.Molecular features of interleukin-1 receptor-associated kinase-b and a in Mytilus coruscus, regulating their function by infection of aquatic pathogens and the expression of their serine/threonine protein kinase functional domains. Fish and Shellfish Immunology, 2020, 102: 469-479.
18.Huihui Liu, Meijun Yanga, Xiuqin Tang, Jiaxin Liu, Libing Zheng, Dongdong Xu, Changfeng Chi, Zhenming Lv. Molecular insights of a novel fish Toll-like receptor 9 homologue in Nibea albiflora to reveal its function as PRRs. Fish and Shellfish Immunology, 2021, 118: 321-332.
19.Yibo Sun, Weimin Liao, Yue Liu, Libing Zheng , Dongdong Xu, Changfeng Chi, Zhenming Lv ,Huihui Liu（通讯）. Molecular insights of the class A scavenger receptor, macrophage receptor with collagenous structure (MARCO) in Nibea albiflora. Aquaculture Reports, 2021, 21 : 100867
获奖及专利
1.刘慧慧，薛超波.滩涂贝类养殖环境的细菌分布..舟山市自然科学优秀论文奖。
2.刘慧慧，薛超波，常抗美，杨刚.厚壳贻贝M7 lysin分子的克隆与表达.舟山市自然科学优秀论文奖。
3.王萍亚，薛超波，刘慧慧，黄朱梁，孙瑛，周勇.水产品中致病性弧菌基因芯片检测技术的建立与应用，舟山市人民政府，二等奖。
4．刘慧慧.大黄鱼小瓜虫病的防治.浙江省优秀研究生教学案例.
