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刘慧慧

作者: 时间:2020-05-20 点击数:

4C5B

姓名:刘慧慧

职称:教授

学术职衔:硕士生导师

荣誉称号:新世纪111人才工程第二层次

研究方向:海洋生物学

Email:liuhuihui2004@126.cm

学习工作简历

1997年9月至2001年7月辽宁师范大学生命科学学院学士

2001年9月至2004年7月宁波大学生命科学与生物工程学院硕士

2004年8月至2014年11月浙江海洋大学海洋科学与技术学院讲师

2008年9月至2014年6月浙江大学生命科学学院博士(在职)

2014年12月起浙江海洋大学海洋科学与技术学院教授

教学情况

承担本科生课程《分子生物学(双语)》、《现代生物技术》、《基因工程》、《蛋白质工程》

研究生课程《高级分子生物学》、《现代生物技术》

指导本科生毕业设计和课程设计

科研项目

(1)国家星火计划项目,曼氏无针乌贼抗病苗种培育技术研发与示范,项目编号:2012GA700111,2012.01-2013.12。课题主持人。

(2)浙江省自然科学基金,TLR介导曼氏无针乌贼抗哈维氏弧菌感染的机制与功能,项目编号:LY14C190004,2014.01-2016.12。课题主持人。

(3)舟山市科技计划项目,拟目乌贼抗逆苗种选育关键技术研发与示范,项目编号:2015C41014,2015.09-2018.09。课题主持人。

(4)国家自然科学基金,大黄鱼清道夫受体MARCO抗哈维氏弧菌感染的分子机制,项目编号:41606148,2017.01-2019.12。课题主持人。

(5)浙江省自然科学基金,黄姑鱼清道夫受体MARCO内吞机制及其在免疫应答中的功能,项目编号:LY20C190006,2020.01-2022.12。课题主持人。

代表性论文著作

1.Hui-Hui Liu,Li-Xin Xiang, Jian-Zhong Shao. A novel C1q-domain-containing (C1qDC) protein from Mytilus coruscus with the transcriptional analysis against marine pathogens and heavy metals.Developmental and Comparative Immunology. 2014,44:70-75.

2.Hui-hui Liu,Jian-yu He,Chang-feng Chi,Jianzhong Shao.Differential HSP70 expression inMytilus coruscusunder various stressors. Gene, 2014,543:166-173.

3. Jian-yu He,Chang-feng Chi,Hui-hui Liu(通讯). Identification and analysis of an intracellular Cu/Zn superoxide dismutase from Sepiella maindroni under stress of Vibrio harveyi and Cd2+. Developmental and Comparative Immunology. 2014, 47 :1–5.

4. Jianyu He,Huihui Liu, Changwen Wu. Identification of SCARA3, SCARA5 and MARCO of class A scavenger receptor-like family in Pseudosciaena crocea. Fish & Shellfish Immunology. 2014, 41:238-249.

5.Huihui Liu,Jianyu He, Changfeng Chi,Yifeng Gu. Identification and analysis of icCu/Zn-SOD, Mn-SOD and ecCu/Zn-SOD in superoxide dismutase multigene family ofPseudosciaena crocea. Fish & Shellfish Immunology, 2015, 43: 491-501.

6.Jianyu He, Wei Liu, Shaoping Wang, Wan Liu,Huihui Liu(通讯). The SREC-I and SREC-II associated with epidermal growth factor in scavenger receptor family are the potential regulative transmembrane receptors inLarimichthys crocea. Fish & Shellfish Immunology, 2015, 47:182-195.

7.Huihui Liu, Jianyu He, Rongtao Zhao, Changfeng Chi, Yongbo Bao. A novel biomarker for marine environmental pollution of pi-class glutathione S-transferase fromMytilus coruscus. Ecotoxicology and Environmental Safety, 2015, 118: 47-54.

8.Hui-hui Liu, Jian-yu He, Chang-feng Chi, Zhen-ming Lv. Identification and analysis of HSP70 fromSepiella maindroniunder stress ofVibrio harveyiand Cd2+.Gene, 2015,572:146-152.

9.Jian-yu He, Junru Wang, Mengshan Xu, Changwen Wu,Huihui Liu(通讯).The cooperative expression of Heat Shock Protein 70 KD and 90 KDgene in juvenileLarimichthys croceaunderVibrio alginolyticusstress. Fish & Shellfish Immunology , 2016,58: 359-369.

10.Hui-hui Liu,Jiong Wu, Mengshan Xu, Jianyu He.A novel biomarker for marine environmental pollution of HSP90 fromMytilus coruscus. Marine Pollution Bulletin, 2016,111, 428–434.

11.Jianyu He,Hui-hui Liu,JingwenYang,XiangliDong,Changwen Wu.Abundant members of Scavenger receptors family and their identification, characterization and expression againstVibrio alginolyticusinfection in juvenileLarimichthys crocea.Fish & Shellfish Immunology , 2016, 50: 297-309.

12 Jiong Wu, Miaomiao Bao, Delong Ge, Liping Huo, Zhenming Lv, Changfeng Chi, Zhi Liao, Huihui Liu(通讯).The expression of superoxide dismutase in Mytilus coruscus undervarious stressors.Fish & Shellfish Immunology. 2017,70 :361-371.

12.Mengshan Xu, Jiong Wu, Delong Ge, Changwen Wu, Changfeng Chi, Zhenming Lv, Zhi Liao,Huihui Liu(通讯). A novel toll-like receptor from Mytilus coruscus is induced in response to stress.Fish & Shellfish Immunology. 2018,78:331-337.

13.Liping Huo, Miaomiao Bao, Zhenming Lv, Changfeng Chi, Tianming Wang,Huihui Liu(通讯). Identification, functional characterization andexpression pattern of myeloid differentiation factor 88 (MyD88) in Sepiella japonica[J]. Fish and Shellfish Immunology, 2018, 79: 112-119.

14.Miaomiao Bao, Liping Huo, Jiong Wu, Delong Ge, Zhenming Lv, Changfeng Chi, Zhi Liao,Huihui Liu(通讯).A novel biomarker for marine environmental pollution of CAT from Mytilus coruscus. Marine Pollution Bulletin, 2018,127:717-725.

15.Huihui Liu, Liping Huo, Qiuhan Yu, Delong Ge, Changfeng Chi∗, Zhenming Lv, Tianming Wang.Molecular insights of a novel cephalopod toll-like receptor homologue in Sepiella japonica, revealing its function under the stress of aquatic pathogenic bacteria. Fish and Shellfish Immunology, 2019, 90: 297-309.

16.Junxi Xiang, Ruiyi Chen, Dongdong Xu,Yibo Sun,Huihui Liu(通讯). Characterization of pathological changes and immune-related gene expression in yellow drum (Nibea albiflora) in response to Pseudomonas plecoglossicida and poly I:C challenge. Aquaculture Reports, 2020,17:100350.

17.Sijia Liu, Delong Ge, Zaihao Long, Changfeng Chi, Zhenming Lv,Huihui Liu(通讯).Molecular features of interleukin-1 receptor-associated kinase-b and a in Mytilus coruscus, regulating their function by infection of aquatic pathogens and the expression of their serine/threonine protein kinase functional domains. Fish and Shellfish Immunology, 2020, 102: 469-479.

18.Huihui Liu, Meijun Yanga, Xiuqin Tang, Jiaxin Liu, Libing Zheng, Dongdong Xu, Changfeng Chi, Zhenming Lv. Molecular insights of a novel fish Toll-like receptor 9 homologue in Nibea albiflora to reveal its function as PRRs. Fish and Shellfish Immunology, 2021, 118: 321-332.

19.Yibo Sun, Weimin Liao, Yue Liu, Libing Zheng , Dongdong Xu, Changfeng Chi, Zhenming Lv ,Huihui Liu(通讯). Molecular insights of the class A scavenger receptor, macrophage receptor with collagenous structure (MARCO) in Nibea albiflora. Aquaculture Reports, 2021, 21 : 100867

获奖及专利

1.刘慧慧,薛超波.滩涂贝类养殖环境的细菌分布..舟山市自然科学优秀论文奖。

2.刘慧慧,薛超波,常抗美,杨刚.厚壳贻贝M7 lysin分子的克隆与表达.舟山市自然科学优秀论文奖。

3.王萍亚,薛超波,刘慧慧,黄朱梁,孙瑛,周勇.水产品中致病性弧菌基因芯片检测技术的建立与应用,舟山市人民政府,二等奖。

4.刘慧慧.大黄鱼小瓜虫病的防治.浙江省优秀研究生教学案例.

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