姓 名: 杨静文

职 称: 教授

导师身份: 浙江海洋大学硕士生导师

研究方向: 海洋生物学 分子及细胞生物学方向

Emai：yangjingwen@zjou.edu.cn

学习工作简历

2003年9月至2007年7月 山东理工大学 学士

2007年9月至2010年7月 中国科学院海洋研究所 硕士

2010年9月至2013年6月 浙江大学动物科学学院 博士

2013年7月至2018年8月 浙江海洋大学海洋科学与技术学院 讲师

2017年9月至2018年9月 加州大学旧金山分校CSC访问学者

2018年9月至2022年12月 浙江海洋大学海洋科学与技术学院 副教授

2023年1月至今 浙江海洋大学海洋科学与技术学院 教授

研究兴趣

GPCR参与的海洋生物生理功能调控

海洋生物神经内分泌调控网络

科研项目

1、大黄鱼褪黑素信号系统特征及其生殖调控机理研究(42076130)，国家自然科学基金面上项目，2021.01-2024.12（主持）

2、大黄鱼神经肽Y2亚族受体的信号转导机制及其生理功能研究(41606150)，国家自然科学基金青年项目，2017.01-2019.12（主持）

3、刺参CRH/CRHR系统特征及其夏眠调控研究(2019C21020)，舟山市科学技术项目，2019.01-2021.12（主持）

4、曼氏无针乌贼生殖生长调控神经肽高活性表达研究及评价(2017C32074)，浙江省公益技术研究项目，2016.07-2018.06（主持）

5、刺参生殖与夏眠生理状态转变的神经内分泌调控特征及机理研究(32072952)，国家自然科学基金面上项目2021.01-2024.12（主要参与人）

6、刺参Kisspeptin/GPR54系统特征及其生殖调控机制研究(41876154)，国家自然科学基金面上项目2019.01-2022.12（主要参与人）

代表性论文著作

1. Jiaqian Feng^#,Jingwen Yang^#, Zhijing Jiang^#, Naiming Zhou, Xue Liu, Guangbo Zhang, Xiaojun Yan, Jixiu Wang, Xiuwen Xu, Su Guo, Tianming Wang. Melatonin modulates the hypothalamic-pituitary neuroendocrine axis to regulate physiological color change in teleost fish. International Journal of Biological Sciences, 2023, 19(9): 2914-2933.

2. Xue Liu, Jiaqian Feng, Zhijing Jiang, Guangbo Zhang, Xiuwen Xu, Jixiu Wang,Jingwen Yang^*and Tianming Wang^*. Functional characterization of two corticotropin-releasing hormone receptors inLarimichthys crocea. Frontiers in Marine Science. 2023, 10: 1-14.

3. Jieyi Yuan^#,Jingwen Yang^#, Xiuwen Xu, Zexianghua Wang, Zhijing Jiang, Zhiqing Ye, Yucheng Ren, Qing Wang and Tianming Wang^*. Bisphenol A (BPA) Directly Activates the G Protein-Coupled Estrogen Receptor 1 and Triggers the Metabolic Disruption in the Gonadal Tissue ofApostichopus japonicus. Biology, 2023, 12(6):798.

4. Dexiang Huang, Bing Zhang, Tao Han, Guangbin Liu, Xu Chen, Zihao Zhao, Jiaqian Feng,Jingwen Yang^*, Tianming Wang^*. Genome-wide prediction and comparative transcriptomic analysis reveals the G protein-coupled receptors involved in gonadal development ofApostichopus japonicus. Genomics, 2021, 113(1 Pt 2): 967-978.

5. Tianming Wang, Jing Liang, Xiaowei Xiang, Xu Chen, Bing Zhang, Naiming Zhou, Wei Huang,Jingwen Yang*. Pharmacological characterization, cellular localization and expression profile of NPY receptor subtypes Y2 and Y7 in large yellow croaker,Larimichthys crocea. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2019, 238:110347.

6. Jiaqian Feng, Tao Han, Yuexing Zhang, Bing Zhang, Dexiang Huang, Tianming Wang,Jingwen Yang^*. Molecular characterization and biological function of CXCR1 in Nocardia seriolae-infected largemouth bass (Micropterus salmoides). Tissue Cell, 2021, 72:101551.

7. Tianming Wang^#, Zheng Cao^#, Zhangfei Shen^#,Jingwen Yang, Xu Chen, Zhen Yang, Ke Xu, Xiaowei Xiang, Qiuhan Yu, Yimin Song, Weiwei Wang, Yanan Tian, Lina Sun, Libin Zhang, Su Guo, Naiming Zhou. Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species. Elife, 2020, 9: e53370.

8.Tianming Wang, Xu Chen, Ke Xu, Bing Zhang, Dexiang Huang,Jingwen Yang^*. Apoptosis Induction and Detection in a Primary Culture of Sea Cucumber Intestinal Cells. Journal of Visualized Experiments, 2020, 155.

9.Tianming Wang*, Jing Liang, Xiaowei Xiang, Jiajie Yuan, Xu Chen, Xingwei Xiang,Jingwen Yang^*. Functional identification and expressional responses of large yellow croaker (Larimichthys crocea) interleukin-8 and its receptor. Fish & Shellfish Immunology, 2019, 87: 470-477

10.Jingwen Yang,Yuchao Xu, Ke Xu, Hongling Ping, Huilai Shi, Zhenming Lv, Changwen Wu, Tianming Wang*. Molecular cloning and transcriptional analysis of a npy receptor-like in common chinese cuttlefishSepiella japonica. Chinese Journal of Oceanology and Limnology, 2018, 36(3): 892-904

11.Jingwen Yang，Yunjun Yan，Xiaowei Xiang，Yuchao Xu，Naiming Zhou*，Tianming Wang*，Detection of ligand-activated G protein coupled receptor internalization by confocal microscopy. Journal of Visualized Experiments, 2017, (122):55514

12.Jingwen Yang,Zhangfei Shen, Xue Jiang, Huipeng Yang, Haishan Huang, Lili Jin, Yajie Chen, Liangen Shi^*, Naiming Zhou^*. Agonist-activatedBombyxcorazonin receptor is internalized via an arrestin-dependent and clathrin-independent pathway. Biochemistry, 2016, 55(28): 3874-3887

13.Jingwen Yang, Huihui Liu, Gang Zheng, Xiaowei Xiang, Zhenming Lv^*, Tianming Wang^*. Cathepsin L of the sea cucumberApostichopus japonicusmolecular characterization and transcriptional response to Vibrio splendidus infection. Fish & Shellfish Immunology, 2016, 49: 387-395

14. Yunjun Yan, Tianming Wang, Wan Liu, Changwen Wu, Aiyi Zhu, Changfeng Chi, Zhenming Lv*,Jingwen Yang^*. Identification and Expression Profile of the Gonadotropin-Releasing Hormone Receptor in Common Chinese Cuttlefish,Sepiella japonica. Journal of Experimental Zoology Part A-Ecological Genetics and Physiology, 2016, 325(7): 453-466

15. Zhenming Lv, Wan Liu, Liqing Liu, Tianming Wang, Huilai Shi, Hongling Ping, Changfeng Chi,Jingwen Yang^*, Changwen Wu. Cloning, Characterization, and Expression Profile of Estrogen Receptor in Common Chinese Cuttlefish,Sepiella japonica. Journal of Experimental Zoology Part A-Ecological Genetics and Physiology, 2016, 325(3): 181-193

16.Jingwen Yang, Haishan Huang, Huipeng Yang, Xiaobai He, Xue Jiang, Ying Shi, Damirin Alatangaole, Liangen Shi*, Naiming Zhou*. Specific activation of the G protein-coupled receptor BNGR-A21 by the neuropeptide corazonin from the silkworm,Bombyx mori, dually couples to the G(q) and G(s) signaling cascades. Journal of Biological Chemistry, 2013, 288(17): 11662-11675

17.Jingwen Yang, Suping Zhang*. The radular morphology of Nassariidae (Gastropoda: Caenogastropoda) from China, Chinese Journal of Oceanology and Limnology, 2011, 29(5): 1023-1032

18.Jingwen Yang, Suping Zhang*. A new spceies ofNassarius(Gastropoda, Nassariidae) from the northern China seas, Acta Oceanologica Sinica, 2011, 30(6): 82-85