个人简介
姓名：周扬
职称：副研究员
学术职衔：硕士生导师
研究方向：药物化学、生物医用凝胶
邮箱：zhouyang876@nimte.ac.cn
工作和教育背景：
2017年11月—至今，中国科学院宁波材料技术与工程研究所慈溪生物医学工程研究所，副研究员；
2014年1月—2017年11月，南京大学生命科学学院药学专业，博士后，导师：朱海亮教授；
2014年2月—2015年4月，韩国国立蔚山科学技术大学多维碳材料中心，博士后，导师：Christopher W. Bielawski教授；
2008年9月—2013年6月，南京大学生命科学学院生物学专业，获博士学位，导师：赵劲教授；
2004年9月—2008年6月，中国药科大学药学院药剂学专业，获学士学位。
近5年代表性论文著作
(1) Juan Sun*, Ze-Yu Fang, Yi-Nuo Tao, Yi-Heng Zhang, Yao Zhang, Hai-Ya Sun,Yang Zhou*, Yuan-Feng Wu*.Design, synthesis and antitumor activity of FAK/PLK1 dual inhibitorswith quinazolinone as the skeleton.Chem. Biodiversity2023,20, e202300146.
(2) Juan Sun*, Cui-Ping Zhang, Chong-Hao Chen, Xiao-Meng Guo, Cai-Shi Liu,Yang Zhou*, Fu-Liang Hu*.Design, synthesis and molecular docking of 1,3,4-Oxadiazole-2(3H)-thione derivatives containing 1,4-benzodioxane skeleton aspotential FabH inhibitors.Chem. Biodiversity2023,20, e202201060.
(3)Shuai-Jun Guo, Hao-Yun Chang, Meng-Jia Xu, Chen-Xu Wang, Hua Wei, Dong-Dong Li, Jing Chen*,Yang Zhou*, Yi Liu*. Co2+-mediated hydrogels with enhanced mechanical properties for flexible sensing.ACS Appl. Polym. Mater.2022，4，6403-6413.
(4)Yang Zhou, Yin-Qiu Liang, Xin-Yu Wang, Hao-Yun Chang, Su-Pei Hu*, Juan Sun*. Design, synthesis and antibacterial activities of novel amide derivatives bearing dioxygenated rings as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors.Chem. Pharm. Bull.2022,70, 544-549.
(5) Peng An, Hua Wei, Yan-Sheng Zhang,Yang Zhou, Hua Zhang*, Wen-Feng Li,Bao-Long Niu*, Jing Chen*.A mechanically adaptive “all-sugar” hydrogel for cell-laden injection.Eur. Polym. J.2022,174, 111328.
(6) Juan Sun*, Yue-Hu Chen, Han-Yu Liu, Emmerson Hondo,Yang Zhou*, Yuan-Feng Wu*. Thiazolidinedione: A privileged scaffold for the development of anticancer agents.Curr. Top. Med. Chem.2021,21, 2529-2545.
(7)Hua Wei, Zhen-Wu Wang, Hua Zhang, You-Ju Huang*, Zong-Bao Wang,Yang Zhou, Ben-Bin Xu*,Sami Halila, and Jing Chen*.Ultrastretchable, highly transparent, self-adhesive, and 3D-printable ionic hydrogels for multimode tactical sensing.Chem. Mater.2021,33, 6731-6742.
(8) Hua Zhang, Ting Xu, Dong-Dong Li, Tao Cheng, Jing Chen∗,Yang Zhou∗. Gold complexes of bis-indazole-derivedN-Heterocyclic carbene:synthesis, structural characterizations, and catalysis.J. Mol. Struct.2021,1233, 130043.
(9) Amarachi Rosemary Osi, Hua Zhang, Jing Chen,Yang Zhou, Rong Wang, Jun Fu*,Peter Müller-Buschbaum, Qi Zhong. Three-dimensional-printable thermo/photo-cross-linkedmethacrylated chitosan−gelatin hydrogel composites for tissueengineering.ACS Appl. Mater. Interfaces2021,13, 22902-22913.
(10) Xin-Jie Pei, Hua Zhang,Yang Zhou, Lin-Jie Zhou and Jun Fu∗. Stretchable, self-healing and tissue-adhesivezwitterionic hydrogels as strain sensors forwireless monitoring of organ motions.Mater. Horiz.2020,7, 1872-1882(年度杰出论文奖).
(11) Hua Zhang, Yang Cong, Amarachi Rosemary Osi,Yang Zhou,Fang-Cheng Huang,Remo P. Zaccaria, Jing Chen, Rong Wang, and Jun Fu∗.Direct 3D printed biomimetic scaffolds based on hydrogelmicroparticles for cell spheroid growth.Adv. Funct. Mater.2020,30, 1910573.
(12) Hua Zhang, Peng-Gang Ren, Hua Wei, Sami Halila, Amarachi Osi,Yang Zhou*, Zhong Dai, Rong Wang, Jing Chen*. Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent.Soft Matter2020,16, 8647-8654.
(13) Hua Zhang, Peng-Gang Ren, Fan Yang, Jing Chen, Chen-Xu Wang,Yang Zhou, Jun Fu*. Biomimetic epidermal sensors assembled from polydopamine-modified reduced graphene oxide/polyvinyl alcohol hydrogels for the real-time monitoring of human motions.J. Mater. Chem. B2020,8,10549-10558.
(14) Hua Wei, Hua Zhang,Yang Zhou∗, Zong-Bao Wang, Rong Wang, Jing Chen. Understanding of growth mechanism and structure ofmultilayer thin films via layer-by-layer hydrogenbonded assembly from polymer brushes-grafted surface.Nanosci. Nanotechnol. Lett.2020,12, 890-900.
(15)Kun Fang, Rong Wang*, Hua Zhang, Lin-Jie Zhou, Ting Xu, Ying Xiao,Yang Zhou, Guo-Rong Gao, Jing Chen, Donglei Liu*, Fan-Rong Ai, and Jun Fu*. Mechano-responsive, tough, and antibacterial zwitterionic hydrogels with controllable drug Release for wound healing applications.ACS Appl Mater Interfaces2020,12, 52307-52318.
(16) Yong Yin†,Yang Zhou†(共同一作), Shao Sha, Xun Wu, She-Feng Wang, Fang Qiao,Zhong-Cheng Song*, Hai-Liang Zhu*. Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivatescontaining piperazine as inhibitors of PI3Kα.Bioorg. Chem.2019,92, 103238.
(17) Xu-Ping Zhang, Tian-Tian Wang, Zeng-Hui Yuan,Yang Zhou∗,Yu-Shun Yang∗, Hai-Liang Zhu∗.A quinoxalinone-derivated fluorescence sensor with optimized solubility forcysteine detection and biological imaging.Dyes Pigments2019,171, 10771.
(18) Dan Xu, Ting Xu, Guorong Gao, Ying Xiao, Zongbao Wang, Jing Chen,Yang Zhou, Rong Wang, Jingbo Yin, Jun Fu*. Effect of Solvent-Matrix Interactions on Structures and Mechanical Properties of Micelle-Crosslinked Gels.J Polym Sci Part B Polym Phys2019,57, 473-483.
(19) Liu-Fang Wang, Guo-Rong Gao,Yang Zhou, Ting Xu, Jing Chen, Rong Wang, Rui Zhang*, Jun Fu*. Tough, adhensive, self-healable and transparent ionically conductive zwitterionic nanocomposite hydrogels as skin strain.ACS Appl Mater Interfaces2019,11, 3506-3515.
(20)Zhen-Wu Wang, Jing Chen, Liu-Fang wang, Guo-Rong Gao,Yang Zhou, Rong Wang, Ting Xu, Jing-Bo Yin*, Jun Fu*.Flexible and wearable strain sensors based on tough and self-adhesive ion conducting hydrogels.J Mater Chem B2019,7, 24-29.
主持并参与项目：
（1）主持：2020年宁波市“科技创新2025”重大专项，项目名称：基于β-酮酰-ACP缩合酶的新型多靶点抗菌药物开发，起止时间：2020.9-2024.8
（2）主持：2020年国家青年基金，项目名称：基于β-酮酰-ACP缩合酶的多靶点硫内酯霉素结构修饰与抗菌活性研究，起止时间：2021.1-2023.12
（3）主持：2019年浙江省青年基金，项目名称：新型硫脲-醚甜菜碱两性离子水凝胶的合成、力学性能、自愈性能及抗粘附性研究，起止时间：2019.1-2021.12
（4）主持：2014年中国博士后科学基金第56批面上，项目名称：新型FabH抑制剂的设计，合成及广谱抗菌活性研究，起止时间：2014.8-2015.7
（5）参与：国家重点研发计划-政府间国际科技创新合作重点专项（子课题负责），项目名称：骨诱导及抗菌型超高分子量聚乙烯-多孔钛涂层人工关节关键技术研究，项目经费：94万，起止时间：2020.1-2022.12。
