姓名：刘慧慧
职称：教授
学术职衔：博士生导师
研究方向：海洋生物学
Email：liuhuihui2004@126.cm
学习工作简历
2001年9月至2004年7月宁波大学生命科学与生物工程学院硕士
2004年8月至2014年11月浙江海洋大学海洋科学与技术学院讲师
2008年9月至2014年6月浙江大学生命科学学院博士（在职）
2014年12月-2021年11月浙江海洋大学海洋科学与技术学院副教授
2021年12月-至今浙江海洋大学海洋科学与技术学院教授
教学情况
承担本科生课程《分子生物学（双语）》、《现代生物技术》、《基因工程》、《蛋白质工程》
研究生课程《高级分子生物学》、《现代生物技术》
指导本科生毕业设计和课程设计
科研项目
（1）国家星火计划项目，曼氏无针乌贼抗病苗种培育技术研发与示范，项目编号：2012GA700111，2012.01-2013.12。课题主持人。
（2）浙江省自然科学基金，TLR介导曼氏无针乌贼抗哈维氏弧菌感染的机制与功能，项目编号：LY14C190004，2014.01-2016.12。课题主持人。
（3）舟山市科技计划项目，拟目乌贼抗逆苗种选育关键技术研发与示范，项目编号：2015C41014，2015.09-2018.09。课题主持人。
（4）国家自然科学基金，大黄鱼清道夫受体MARCO抗哈维氏弧菌感染的分子机制，项目编号：41606148，2017.01-2019.12。课题主持人。
（5）浙江省自然科学基金，黄姑鱼清道夫受体MARCO内吞机制及其在免疫应答中的功能，项目编号：LY20C190006，2020.01-2022.12。课题主持人。
（6）国家自然科学基金，基于大黄鱼基因组序列发掘其A类清道夫受体内吞机制及在免疫应答中的功能，项目编号：32273162，2023.01-2026.12。课题主持人。
（7）舟山市科技计划项目，黄姑鱼白细胞介素-10（IL-10）的免疫调节功能与作用机制，项目编号：2023C41014，2023.01-2025.12。课题主持人。
（8）省属高校基本科研业务费，黄姑鱼干扰素-γ（IFN-γ）的免疫调节功能与抗感染机制探究， 项目编号：2024J005-3，2024.01-2025.12。课题主持人。
代表性论文著作
1.Hui-Hui Liu，Li-Xin Xiang, Jian-Zhong Shao. A novel C1q-domain-containing (C1qDC) protein from Mytilus coruscus with the transcriptional analysis against marine pathogens and heavy metals.Developmental and Comparative Immunology. 2014，44：70-75.
2.Hui-hui Liu，Jian-yu He，Chang-feng Chi，Jianzhong Shao.Differential HSP70 expression inMytilus coruscusunder various stressors. Gene, 2014，543：166-173.
3. Jian-yu He，Chang-feng Chi,Hui-hui Liu(通讯）. Identification and analysis of an intracellular Cu/Zn superoxide dismutase from Sepiella maindroni under stress of Vibrio harveyi and Cd2 . Developmental and Comparative Immunology. 2014, 47 :1–5.
4. Jianyu He,Huihui Liu, Changwen Wu. Identification of SCARA3, SCARA5 and MARCO of class A scavenger receptor-like family in Pseudosciaena crocea. Fish & Shellfish Immunology. 2014, 41:238-249.
5.Huihui Liu，Jianyu He, Changfeng Chi，Yifeng Gu. Identification and analysis of icCu/Zn-SOD, Mn-SOD and ecCu/Zn-SOD in superoxide dismutase multigene family ofPseudosciaena crocea. Fish & Shellfish Immunology, 2015, 43: 491-501.
6.Jianyu He, Wei Liu, Shaoping Wang, Wan Liu,Huihui Liu(通讯）. The SREC-I and SREC-II associated with epidermal growth factor in scavenger receptor family are the potential regulative transmembrane receptors inLarimichthys crocea. Fish & Shellfish Immunology, 2015, 47:182-195.
7.Huihui Liu, Jianyu He, Rongtao Zhao, Changfeng Chi, Yongbo Bao. A novel biomarker for marine environmental pollution of pi-class glutathione S-transferase fromMytilus coruscus. Ecotoxicology and Environmental Safety, 2015, 118: 47-54.
8.Hui-hui Liu, Jian-yu He, Chang-feng Chi, Zhen-ming Lv. Identification and analysis of HSP70 fromSepiella maindroniunder stress ofVibrio harveyiand Cd2 .Gene, 2015，572：146-152.
9.Jian-yu He, Junru Wang, Mengshan Xu, Changwen Wu,Huihui Liu（通讯）.The cooperative expression of Heat Shock Protein 70 KD and 90 KDgene in juvenileLarimichthys croceaunderVibrio alginolyticusstress. Fish & Shellfish Immunology , 2016,58: 359-369.
10.Hui-hui Liu,Jiong Wu, Mengshan Xu, Jianyu He.A novel biomarker for marine environmental pollution of HSP90 fromMytilus coruscus. Marine Pollution Bulletin, 2016,111, 428–434.
11.Jianyu He,Hui-hui Liu,JingwenYang,Xiangli Dong,Changwen Wu.Abundant members of Scavenger receptors family and their identification, characterization and expression againstVibrio alginolyticusinfection in juvenileLarimichthys crocea.Fish & Shellfish Immunology , 2016, 50: 297-309.
12 Jiong Wu, Miaomiao Bao, Delong Ge, Liping Huo, Zhenming Lv, Changfeng Chi, Zhi Liao, Huihui Liu（通讯）.The expression of superoxide dismutase in Mytilus coruscus undervarious stressors.Fish & Shellfish Immunology. 2017，70 ：361-371.
12.Mengshan Xu, Jiong Wu, Delong Ge, Changwen Wu, Changfeng Chi, Zhenming Lv, Zhi Liao,Huihui Liu（通讯）. A novel toll-like receptor from Mytilus coruscus is induced in response to stress.Fish & Shellfish Immunology. 2018，78：331-337.
13.Liping Huo, Miaomiao Bao, Zhenming Lv, Changfeng Chi, Tianming Wang,Huihui Liu（通讯）. Identification, functional characterization andexpression pattern of myeloid differentiation factor 88 (MyD88) in Sepiella japonica[J]. Fish and Shellfish Immunology, 2018, 79: 112-119.
14.Miaomiao Bao, Liping Huo, Jiong Wu, Delong Ge, Zhenming Lv, Changfeng Chi, Zhi Liao,Huihui Liu（通讯）.A novel biomarker for marine environmental pollution of CAT from Mytilus coruscus. Marine Pollution Bulletin, 2018,127：717-725.
15.Huihui Liu, Liping Huo, Qiuhan Yu, Delong Ge, Changfeng Chi∗, Zhenming Lv, Tianming Wang.Molecular insights of a novel cephalopod toll-like receptor homologue in Sepiella japonica, revealing its function under the stress of aquatic pathogenic bacteria. Fish and Shellfish Immunology, 2019, 90: 297-309.
16.Junxi Xiang, Ruiyi Chen, Dongdong Xu,Yibo Sun,Huihui Liu（通讯）. Characterization of pathological changes and immune-related gene expression in yellow drum (Nibea albiflora) in response to Pseudomonas plecoglossicida and poly I:C challenge. Aquaculture Reports, 2020，17：100350.
17.Sijia Liu, Delong Ge, Zaihao Long, Changfeng Chi, Zhenming Lv,Huihui Liu（通讯）.Molecular features of interleukin-1 receptor-associated kinase-b and a in Mytilus coruscus, regulating their function by infection of aquatic pathogens and the expression of their serine/threonine protein kinase functional domains. Fish and Shellfish Immunology, 2020, 102: 469-479.
18.Huihui Liu, Meijun Yanga, Xiuqin Tang, Jiaxin Liu, Libing Zheng, Dongdong Xu, Changfeng Chi, Zhenming Lv. Molecular insights of a novel fish Toll-like receptor 9 homologue in Nibea albiflora to reveal its function as PRRs. Fish and Shellfish Immunology, 2021, 118: 321-332.
19.Yibo Sun, Weimin Liao, Yue Liu, Libing Zheng , Dongdong Xu, Changfeng Chi, Zhenming Lv ,Huihui Liu（通讯）. Molecular insights of the class A scavenger receptor, macrophage receptor with collagenous structure (MARCO) in Nibea albiflora. Aquaculture Reports, 2021, 21 : 100867.
20.Xiuqin Tang, Meijun Yang, Jiaxin Liu, Libing Zheng, Dongdong Xu, Changfeng Chi, Zhenming Lv,Huihui Liu（通讯）. Identification, functional characterization and expression pattern of myeloid differentiation factor 88 (MyD88) in Nibea albiflora. Fish and Shellfish Immunology, 2022, 124: 380-390.
21.Xiaoxian Guo, Yue Liu, Jiaxin Liu, Dongdong Xu, Changfeng Chi, Zhenming Lv,Huihui Liu（通讯）, Sequence and functional features of a novel scavenger receptor homolog, SCARA5 from Yellow drum (Nibea albiflora). Developmental and Comparative Immunology, 2022,135: 104463.
22.Jiaxin Liu, Yue Liu , Yongxin Liu, Xiaoxian Guo , Zhenming Lü, Xu Zhou,Huihui Liu（通讯）, Changfeng Chi. Molecular cloning, expression analysis and immune-related functional identification of tumor necrosis factor alpha (TNFα) in Sepiella japonica under bacteria stress. Fish and Shellfish Immunology, 2023, 132: 108509.
23. Yongxin Liu, Kaihui Li, Mingming Wenren, Wei Cheng, Xu Zhou，Dongdong Xu, Changfeng Chi, Zhenming Lü,Huihui Liu（通讯）, Identification, functional characterization and expression pattern of interferon-gamma (IFN-γ) and interferon-gamma receptor 1 (IFNGR1) in Nibea albiflora. Fish and Shellfish Immunology，2024，147：109274.
24.Yue Liu, Mingming Wenren, Wei Cheng, Xu Zhou, Dongdong Xu, Changfeng Chi, Zhenming Lü,Huihui Liu（通讯）. Identification, functional characterization and immune response profiles of interleukin-10 in Nibea albiflora，Fish and Shellfish Immunology，2024，151：109654.
25.Jiaxin Liu, Mingming Wenren, Xu Zhou , Dongdong Xu, Changfeng Chi，Zhenming Lü，Huihui Liu（通讯）. Characterization and functional analysis of interleukin-6 and its receptor subunits (IL-6Rα and IL-6Rβ) in the yellow drum, Nibea alibiflora. Developmental and Comparative Immunology, 2025,162: 105305.
获奖及专利
1.刘慧慧，薛超波.滩涂贝类养殖环境的细菌分布..舟山市自然科学优秀论文奖。
2.刘慧慧，薛超波，常抗美，杨刚.厚壳贻贝M7 lysin分子的克隆与表达.舟山市自然科学优秀论文奖。
3.王萍亚，薛超波，刘慧慧，黄朱梁，孙瑛，周勇.水产品中致病性弧菌基因芯片检测技术的建立与应用，舟山市人民政府，二等奖。
4．刘慧慧.大黄鱼小瓜虫病的防治.浙江省优秀研究生教学案例.
5. 刘慧慧，霍利平，葛德隆. 曼氏无针乌贼 TNF 基因及其用途（ZL201910753116.5）
