姓名：周扬
职称：副研究员
学术职衔：硕士生导师
研究方向：药物化学、生物医用材料
邮箱：zhouyang876@nimte.ac.cn
工作和教育背景：
2017年11月—至今，中国科学院宁波材料技术与工程研究所慈溪生物医学工程研究所，副研究员；
2014年1月—2017年11月，南京大学生命科学学院药学专业，博士后，导师：朱海亮教授；
2014年2月—2015年4月，韩国国立蔚山科学技术大学多维碳材料中心，博士后，导师：Christopher W. Bielawski教授；
2008年9月—2013年6月，南京大学生命科学学院生物学专业，获博士学位，导师：赵劲教授；
2004年9月—2008年6月，中国药科大学药学院药剂学专业，获学士学位。
科研项目：
1. 主持：浙江省联合基金重点项目，项目名称：索马鲁肽长效可注射微球的控制释放机制研究，项目经费：30万，起止时间：2025.1-2027.12。
2. 主持：浙江生基材料科技有限公司，项目名称：***的逆向分析研究，项目经费：60万，起止时间：2025.4.21-2025.7.28.
3. 主持：宁波市青年科技创新领军人才项目，项目名称：以“杀菌-释菌”策略构建的替格瑞洛类FabH抑制剂及其抗菌机理研究，项目经费：50万，起止时间：2024.7-2026.6。
4. 主持：宁波市“科技创新 2025”重大专项，项目名称：基于β-酮酰-ACP缩合酶的新型多靶点抗菌药物开发，项目经费：200万，起止时间：2020.9-2024.8。
5. 主持：国家青年基金，项目名称：基于β-酮酰-ACP缩合酶的多靶点硫内酯霉素结构修饰与抗菌活性研究，项目经费：24万，起止时间：2021.1-2023.12。
6. 主持：浙江省青年基金，项目名称：新型硫脲-醚甜菜碱两性离子水凝胶的合成、力学性能、自愈性能及抗粘附性研究，项目经费：10万，起止时间：2019.1-2022.12。
7. 主持：深圳湾实验室坪山生物医药研发转化中心2023年度基于新颖分子实体的创新药概念验证项目（重点项目），项目名称：基于 KAS 缩合酶的多靶点硫内酯霉素结构修饰与抗菌活性研究，项目经费：8万，起止时间：2023.7-2024.6.
8. 主持：宁波市镇海区人民医院产学研项目，项目名称：用于内科胸腔镜下瘘口注射封堵术治疗难治性气胸的生物医用水凝胶研究，项目经费：5万，起止时间：2020.1-2021.12.
9. 主持：中国博士后科学基金第56批面上，项目名称：新型FabH抑制剂的设计，合成及广谱抗菌活性研究，项目经费：5万，起止时间：2014.8-2015.7。
10. 参与：国家重点研发计划-政府间国际科技创新合作重点专项（子课题负责，前三），项目名称：骨诱导及抗菌型超高分子量聚乙烯-多孔钛涂层人工关节关键技术研究，项目经费：94万，起止时间：2020.1-2022.12。
近5年代表性论文著作
1. Ruiying Ji, Shaopeng Yan, Zhiyu Zhu, Yaping Wang, Dan He, Kaikai Wang, Daofeng Zhou, Qike Jia, Xiuxiu Wang, Botao Zhang, Changcheng Shi, Ting Xu, Rong Wang, Rui Wang, andYang Zhou*. Ureido-ionic liquid mediated conductive hydrogel: superior integrated properties for advanced biosensing applications.Adv. Sci.2024, 11，2401869. (TOP期刊)
2. Haoyun Chang, Ruiyin Ji, Shaopeng Yan, Peng Huang*, Rui Wang*,Yang Zhou*. Target identification, and optimization of dioxygenated amide derivatives as potent antibacterial agents with FabH inhibitory activity.Eur. J. Med. Chem.2024, 265, 116064. (TOP期刊)
3. Juan Sun, Qi Zheng, Yi-Heng Zhang, Cai-Shi Liu, Chong-Hao Chen, Shao-Peng Yan, Xiao-Meng Guo, Su-Pei Hu*,Yang Zhou*, Yuan-Feng Wu*. Structure–activity relationship (SAR) of 18β-glycyrrhetinic acid derivatives on their antitumor activity through the PPARγ receptor and caspase-3 pathway.J. Saudi. Chem. Soc.2024, 28, 101815.
4. Hui Chen, Jiangpo Ma, Feng Zhou, Junhui Yang, Lei Jiang, Quanbing Chen,Yang Zhou*, Jiantao Zhang*. A potential cocrystal strategy to tailor in-vitro dissolution and improve Caco-2 permeability and oral bioavailability of berberine.Int. J. Pharmaceut.2024, 666, 124789. (TOP期刊)
5. Shao-Peng Yan, Zhi-Yu Zhu, Qi-Ke Jia Rui-Ying Ji, Ya-Pin Wang, Dan He, Rong Wang* Xiao-Jun Xu,Yang Zhou*. Synthetic Optimization and Antibacterial Activity of Novel Benzodioxepine-Biphenyl Amide Derivatives.Acta Chim. Slov.2024, 71, 509–518.
6. Jing Wang, Haiyang Fei, Min Zhou, Chengcai Zhang, Juan Sun*,Yang Zhou*, Meng Yang*. Synthesis, Crystal Structures and Antibacterial Activity of Nickel(II) and Copper(II) Complexes Derived from (E)-2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methylene)-N-phenylhydrazinecarbothioamide.Acta Chim. Slov.2024, 71, 20–25.
7. Juan Sun*, Ze-Yu Fang, Yi-Nuo Tao, Yi-Heng Zhang, Yao Zhang, Hai-Ya Sun,Yang Zhou*, Yuan-Feng Wu*. Design, synthesis and antitumor activity of FAK/PLK1 dual inhibitors with quinazolinone as the skeleton.Chem. Biodiversity2023, 20, e202300146.
8. Juan Sun*, Cui-Ping Zhang, Chong-Hao Chen, Xiao-Meng Guo, Cai-Shi Liu,Yang Zhou*, Fu-Liang Hu*. Design, synthesis and molecular docking of 1,3,4-Oxadiazole-2(3H)-thione derivatives containing 1,4-benzodioxane skeleton as potential FabH inhibitors.Chem. Biodiversity2023, 20, e202201060.
9. Hua Wei, Shengkai Yu, Yansheng Zhang, Hua Zhang, Yuxi Ma, Mengjia Xu, Peng An,Yang Zhou, Sami Halila*, Yen Wei*, Jing Chen*. Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair.Carbohyd. Polym.2023, 313, 120904.
10. Shuai-Jun Guo, Hao-Yun Chang, Meng-Jia Xu, Chen-Xu Wang, Hua Wei, Dong-Dong Li, Jing Chen*,Yang Zhou*, Yi Liu*. Co2 -mediated hydrogels with enhanced mechanical properties for flexible sensing.ACS Appl. Polym. Mater.2022，4，6403-6413.
11.Yang Zhou, Yin-Qiu Liang, Xin-Yu Wang, Hao-Yun Chang, Su-Pei Hu*, Juan Sun*. Design, synthesis and antibacterial activities of novel amide derivatives bearing dioxygenated rings as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors.Chem. Pharm. Bull.2022, 70, 544-549.
12. Peng An, Hua Wei, Yan-Sheng Zhang,Yang Zhou, Hua Zhang*, Wen-Feng Li, Bao-Long Niu*, Jing Chen*. A mechanically adaptive “all-sugar” hydrogel for cell-laden injection.Eur. Polym. J.2022, 174, 111328.
13. Juan Sun*, Yue-Hu Chen, Han-Yu Liu, Emmerson Hondo,Yang Zhou*, Yuan-Feng Wu*. Thiazolidinedione: A privileged scaffold for the development of anticancer agents.Curr. Top. Med. Chem.2021, 21, 2529-2545.
14. Hua Wei, Zhen-Wu Wang, Hua Zhang, You-Ju Huang*, Zong-Bao Wang,Yang Zhou, Ben-Bin Xu*, Sami Halila, and Jing Chen*. Ultrastretchable, highly transparent, self-adhesive, and 3D-printable ionic hydrogels for multimode tactical sensing.Chem. Mater.2021, 33, 6731-6742. (TOP期刊)
15. Hua Zhang, Ting Xu, Dong-Dong Li, Tao Cheng, Jing Chen*,Yang Zhou*. Gold complexes of bis-indazole-derived N-Heterocyclic carbene: synthesis, structural characterizations, and catalysis.J. Mol. Struct. 2021,1233, 130043.
16. Amarachi Rosemary Osi, Hua Zhang, Jing Chen,Yang Zhou, Rong Wang, Jun Fu*, Peter Müller-Buschbaum, Qi Zhong. Three-dimensional-printable thermo/photo-cross-linked methacrylated chitosan−gelatin hydrogel composites for tissue engineering.ACS Appl. Mater. Interfaces2021, 13, 22902-22913. (TOP期刊)
17. Xin-Jie Pei, Hua Zhang,Yang Zhou, Lin-Jie Zhou and Jun Fu*. Stretchable, self-healing and tissue-adhesive zwitterionic hydrogels as strain sensors for wireless monitoring of organ motions.Mater. Horiz.2020, 7, 1872-1882 (年度杰出论文奖).
18. Hua Zhang, Yang Cong, Amarachi Rosemary Osi,Yang Zhou, Fang-Cheng Huang, Remo P. Zaccaria, Jing Chen, Rong Wang, and Jun Fu*. Direct 3D printed biomimetic scaffolds based on hydrogel microparticles for cell spheroid growth.Adv. Funct. Mater.2020, 30, 1910573. (TOP期刊)
19. Hua Zhang, Peng-Gang Ren, Hua Wei, Sami Halila, Amarachi Osi,Yang Zhou*, Zhong Dai, Rong Wang, Jing Chen*. Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent.Soft Matter2020,16, 8647-8654.
20. Hua Zhang, Peng-Gang Ren, Fan Yang, Jing Chen, Chen-Xu Wang,Yang Zhou, Jun Fu*. Biomimetic epidermal sensors assembled from polydopamine-modified reduced graphene oxide/polyvinyl alcohol hydrogels for the real-time monitoring of human motions.J. Mater. Chem. B2020, 8, 10549-10558.
21. Hua Wei, Hua Zhang,Yang Zhou*, Zong-Bao Wang, Rong Wang, Jing Chen. Understanding of growth mechanism and structure of multilayer thin films via layer-by-layer hydrogen bonded assembly from polymer brushes-grafted surface.Nanosci. Nanotechnol. Lett.2020, 12, 890-900.
22. Kun Fang, Rong Wang*, Hua Zhang, Lin-Jie Zhou, Ting Xu, Ying Xiao,Yang Zhou, Guo-Rong Gao, Jing Chen, Donglei Liu*, Fan-Rong Ai, and Jun Fu*. Mechano-responsive, tough, and antibacterial zwitterionic hydrogels with controllable drug Release for wound healing applications.ACS Appl Mater Interfaces2020, 12, 52307-52318. (TOP期刊)
