姓 名:王天明
职 称:教 授
导师身份: 浙江海洋大学硕士生导师
研究方向: 海洋生物学 分子及细胞生物学方向
Email:wangtianming@zjou.edu.cn
学习工作简历
2002年9月至2006年7月 浙江大学动物科学学院学士
2006年9月至2011年7月 中国科学院海洋研究所博士(硕博连读)
2011年7月至2013年8月 浙江大学舟山海洋研究中心助理研究员(博士后)
2013年9月至2014年12月 浙江海洋大学海洋科学与技术学院 讲师
2014 年12月至 2019年12月 浙江海洋大学海洋科学与技术学院 副教授
2017年9月-2018年9月 加州大学旧金山分校 CSC访问学者(斑马鱼神经内分泌)
2020年1月至 今 浙江海洋大学海洋科学与技术学院 教授
2015年2月至2016年2月 浙江海洋大学海洋科学与技术学院 生物系主任
2016年3月至 2020年6月 浙江海洋大学海洋科学与技术学院院长助理
2020年6月至 今 浙江海洋大学海洋科学与技术学院 副院长
研究兴趣
神经内分泌及行为学调控研究
细胞信号转导分子机制及生理调控功能研究
海洋生物成体干细胞筛选培养及调控机制研究
科研项目
1、刺参生殖与夏眠生理状态转变的神经内分泌调控特征及机理研究(32072952)国家自然科学基金面上项目2021.01-2024.12 (主持)
2、刺参Kisspeptin/GPR54系统特征及其生殖调控机制研究(41876154)国家自然科学基金面上项目2019.01-2022.12 (主持)
3、重要养殖鲈形目鱼类的摄食生长调控神经肽制备及活性评价(2017C41010)舟山市科技计划研究项目2017.10-2019.09(主持)
4、5-HTR介导的信号转导对刺参夏眠期间摄食的调控及其机理研究(41406137)国家自然科学基金青年项目2015.01-2017.12 (主持)
5、刺参夏眠期间EMP 途径调控过程及机理研究(LY14D060002)浙江省自然科学基金面上项目2014.01- 2016.12 (主持)
6、刺参组织蛋白酶的高效表达及其在胶原酶解中的应用(2013C32056)浙江省公益技术研究项目2013.07-2015.06 (主持)
7、曼氏无针乌贼性成熟调控相关GnRH受体功能研究(20130208)海洋科学重中之重2013-2014开放课题2014.1-2014.12 (主持)
8、曼氏无针乌贼(Speiella maindroni)繁殖调控关键受体信号转导研究(21105012213)Q1313校科研启动经费2013-2017 (主持)
9、曼氏无针乌贼(Sepiella maindroni)神经肽受体NPYR 在性成熟调控中的信号转导机制研究(20140106)国家海洋设施养殖工程技术研究中心2014 年第一批自主选题科研项目2014.01-2015.12 (主持)
10、海地瓜小分子多肽抗氧化作用机制及稳定性研究(BSH1302060)浙江省博士后择优资助项目2013.01-2014.06 (主持)
11、海地瓜酶解多肽的抗氧化功能特性研究(2012C33022)舟山市科技计划项目2012.06-2014.05 (主持)
12、大黄鱼神经肽Y2亚族受体的信号转导机制及其生理功能研究(41606150)国家自然科学基金青年项目2017.01-2019.12 (主要参与人)
13、曼氏无针乌贼生殖生长调控神经肽高活性表达研究及评价(2017C32074) 浙江省公益技术研究项目 2016.07-2018.06 (主要参与人)
代表性论文著作
1. Dexiang Huang, Bing Zhang, Tao Han, Guangbin Liu, Xu Chen, Zihao Zhao, Jiaqian Feng, Jingwen Yang,Tianming Wang*. Genome-wide prediction and comparative transcriptomic analysis reveals the G protein-coupled receptors involved in gonadal development ofApostichopus japonicus[J],Genomics, 2021,113, 967-978.
2.Tianming Wang*, Zheng Cao, Zhangfei Shen, Jingwen Yang, Xu Chen, Zhen Yang, Ke Xu, Xiaowei Xiang, Qiuhan Yu, Yimin Song, Weiwei Wang, Yanan Tian, Lina Sun, Libin Zhang, Su Guo, Naiming Zhou*. Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species[J]. eLife, 2020, 9. 53370
3.Tianming Wang, Xu Chen, Ke Xu, Bing Zhang, Dexiang Huang, Jingwen Yang*. Apoptosis Induction and Detection in a Primary Culture of Sea Cucumber Intestinal Cells[J]. Journal of Visualized Experiments, 2020(155).
4.TianmingWang,Jing Liang, Xiaowei Xiang, Xu Chen, Bing Zhang, Naiming Zhou, Wei Huang, Jingwen Yang*. Pharmacological characterization, cellular localization and expression profile of NPY receptor subtypes Y2 and Y7 in large yellow croaker,Larimichthys crocea[J]. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 2019, 238:110347.
5.Tianming Wang*, Jing Liang, Xiaowei Xiang, Jiajie Yuan, Xu Chen, Xingwei Xiang, Jingwen Yang*.Functional identification and expressional responses of large yellow croaker (Larimichthys crocea) interleukin-8 and its receptor[J].Fish & Shellfish Immunology, 2019, 87: 470-477
6. Ke Xu, Qiuhan Yu, Jianshe Zhang, Zhenming Lv, Wandong Fu,Tianming Wang*. Cell loss by apoptosis is involved in the intestinal degeneration that occurs during aestivation in the sea cucumberApostichopus japonicus[J].Comparative Biochemistry and Physiology B,2018, 216: 25-31
7. Jingwen Yang, Yuchao Xu, Ke Xu, Hongling Ping, Huilai Shi, Zhenming Lv, Changwen Wu,Tianming Wang*. Molecular cloning and transcriptional analysis of a npy receptor-like in common chinese cuttlefishSepiella japonica[J]. Chinese Journal of Oceanology and Limnology, 2018.
8.Tianming Wang*,Zhen Yang,Naiming Zhou*,Lina Sun,Zhenming Lv,Changwen Wu,Identification and functional characterisation of 5-HT4 receptor in sea cucumberApostichopus japonicus(Selenka) [J]. Scientific Reports,2017.1.6,7:40247~40247
9. Jingwen Yang,Yunjun Yan,Xiaowei Xiang,Yuchao Xu,Naiming Zhou*,Tianming Wang*,Detection of ligand-activated G protein coupled receptorinternalization by confocal microscopy[J].Journal of Visualized Experiments, 2017
10.Xiaowei Xiang,Muyan Chen,Changwen Wu,Aiyi Zhu,Jingwen Yang,Zhenming Lv,Tianming Wang*.Glycolytic regulation in aestivation of the sea cucumberApostichopus japonicus: evidence from metabolite quantification and rate-limiting enzyme analyses[J]. Marine biology, 2016,163: 167
11.Jingwen Yang, Huihui Liu, Gang Zheng, Xiaowei Xiang, Zhenming Lv*,Tianming Wang*. Cathepsin L of the sea cucumberApostichopus japonicus-molecular characterization and transcriptional response toVibrio splendidusinfection[J]. Fish & Shellfish Immunology, 2016, 49: 387-395
12.Yunjun Yan,Tianming Wang, Wan Liu, Changwen Wu, Aiyi Zhu, Changfeng Chi, Zhenming Lv*, Jingwen Yang*. Identification and Expression Profile of the Gonadotropin-Releasing Hormone Receptor in Common Chinese Cuttlefish,Sepiella japonica[J].Journal of Experimental Zoology Part A-Ecological Genetics and Physiology, 2016, 325(7): 453-466
13.Zhenming Lv, Wan Liu, Liqing Liu,Tianming Wang, Huilai Shi, Hongling Ping, Changfeng Chi, Jingwen Yang*, Changwen Wu. Cloning, Characterization, and Expression Profile of Estrogen Receptor in Common Chinese Cuttlefish,Sepiella japonica[J]. Journal of Experimental Zoology Part A-Ecological Genetics and Physiology, 2016, 325(3): 181-193
14.Tianming Wang, Lina Sun, Muyan Chen,Aestivation and Regeneration, The sea cucumberApostichopus japonicus: History, Biology and Aquaculture[M]. Developments in Aquaculture and Fisheries Science, 2015, 39, 177-206. Academic Press.
15. Ye Zhao, Muyan Chen, Lin Sua,Tianming Wang, Shilin Liu, Hongsheng Yang*,Molecular cloning and expression-profile analysis of sea cucumber DNA (Cytosine-5)-methyltransferase 1 and methyl-CpG binding domain type 2/3 genes during aestivation[J], CompBiochemPhysB, 2013, 165(1), 26-35.
16.Lin Su, Muyan Chen,Tianming Wang,Jin Liu,Ye Zhao, Hongsheng Yang*,The division of different stages of aestivation and quantitative analysis of tissue layers thickness of anterior intestine in sea cucumberApostichopus japonicus[J],Marine Sciences, 2012, 36(12), 1-5.
17. Lina Sun, Muyan Chen, Hongsheng Yang*,Tianming Wang, Baozhong Liu, Cynthia Shuc, David M. Gardiner, Large scale gene expression profiling during intestine and body wall regeneration in the sea cucumberApostichopus japonicas[J], Comparative Biochemistry and Physiology, Part D , 2011, 6(2), 195-205.
18. Yan Fang, Hongsheng Yang*,Tianming Wang, Baozhong Liu, Heling Zhao, Muyan Chen. Metallothionein and superoxide dismutase responses to sublethal cadmium exposure in the clamMactra veneriformis[J]. Comparative Biochemistry and Physiology C-Toxicology & Pharmacology, 2010, 151(3):325-333.
19.王天明, 杨红生.刺参PDRG基因全长克隆及其夏眠期间在消化道中的表达特征[J].海洋科学, 2013, 12: 1-9.
20.王天明,杨红生,苏琳,夏眠刺参呼吸树抗氧化防御酶类基因表达特征[J].水产学报,2011, 35(8), 1172-1181.